Devil May Cry 5: NVIDIA Control Panel Settings

Ambient Occlusion: Not supported for this application / Off
Anisotropic Filtering: Application controlled (Off for best performance)
Antialiasing – FXAA: Not supported for this application / Off
Antialiasing – Mode: Application controlled
Antialiasing – Setting: (setting will be forced to application controlled if the previous setting is)
Antialiasing – Transparency: Off
Multi-Framed Sampled Antialiasing (MFAA): Off (only works with MSAA, while the game uses FXAA / FXAA+TAA as its Anti-Aliasing options)
CUDA – GPUs: One / All
Maximum pre-rendered frames: Application controlled (try adjusting yourself in the meantime)
Multi-display/mixed-GPU acceleration: Single / Compatibility / Multi display performance mode
Optimise for Compute Performance: Off (may have a negative effect on games if enabled)
Power management mode: Prefer maximum performance (You can try Prefer consistent performance if you wish)
Shader Cache: On (for best performance)
Texture Filtering – Anisotropic Sample Optimisation: Off (“On” for slightly higher performance; slightly degraded visuals)
Texture Filtering – Negative LOD bias: Clamp (“Allow” for slightly higher performance; slightly degraded visuals)
Texture Filtering – Quality: Quality (allows for texture optimisations to take place, select Performance or High Performance for maximum optimisations, select High Quality for maximum quality)
Texture Filtering – Trilinear optimisation: Off (“On” for best performance, this setting is ignored if the previous setting is set to High Quality)
Threaded Optimisation: On / Auto (for best performance, you should find setting this to On will work the best on most CPUs)
Triple Buffering: On (Turn this on if V-Sync is enabled for improved performance, though there may be no effect as this is an OpenGL setting)
Vertical Sync: Use the 3D Application setting
Virtual Reality pre-rendered frames: Use the 3D Application Setting

If you have a G-Sync monitor, enable G-Sync and you should get a smoother experience.